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KMID : 0352720120360010061
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Journal of Ginseng Research
2012 Volume.36 No. 1 p.61 ~ p.67
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Processed Panax ginseng, Sun Ginseng Increases Type I Collagen by Regulating MMP-1 and TIMP-1 Expression in Human Dermal Fibroblasts
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Song Kyu-Choon
Chang Tong-Shin
Lee Hye-jin
Kim Jin-hee
Park Jeong-Hill
Hwang Gwi-Seo
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Abstract
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In the present study, effects of sun ginseng (SG) on the collagen synthesis and the proliferation of dermal fibroblast were investigated. Collagen synthesis was measured by assaying procollagen type I C-peptide production. In addition, the level of matrix metalloproteinase (MMP)-1 was assessed by western blot analysis. SG suppressed the MMP-1 protein level in a dose-dependent manner. In contrast, SG dose-dependently increased tissue inhibitors of MMP (TIMP)-1 production in fibroblasts. SG increased type I collagen production directly and/or indirectly by reducing MMP-1 and stimulating TIMP-1 production in human dermal fibroblasts. SG dose-dependently induced fibroblast proliferation and this, in turn, can trigger more collagen production. These results suggest that SG may be a potential pharmacological agent with anti-aging properties in cultured human skin fibroblast.
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KEYWORD
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Panax ginseng, Sun ginseng (SE), Type I collagen, Matrix metalloproteinase-1, Human skin fibroblasts,
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